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4.4 Summary of the integrated testicular-penile pathological axis The mechanisms described above suggest that varicocele may contribute to ED through a multi-level testicularpenile pathological axis centered on inflammation, oxidative stress, vascular dysfunction, smooth muscle remodeling, and neural injury (111)

A comprehensive 2021 review by Seiwerth and colleagues in Frontiers in Pharmacology surveyed BPC-157 across wound healing contexts including skin, cornea, muscle, tendon, and ligament

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