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The investor state dispute settlement (ISDS) in the Hong Kong treaty allows a single foreign investor, like Philip Morris, to sue the Australian Government for damages in a specially constituted international tribunal if a law or policy, such as the plain packaging legislation, harms an investment

Given that nicotine is an agonist of nAChRs, its chronic exposure may alter receptor sensitivity, potentially offering therapeutic benefits for epilepsy linked to nAChR mutations (34, 3638)

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Collectively, these responses in transcriptional programming and cellular composition are consistent with smoke exposure pushing tuft-like cells toward incomplete or compromised ionocyte or PNEC phenotypes, further supporting our proposed rare cell lineage

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