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One study, for example, treated Sprague Dawley rats treated with gestational nicotine (3 mg/kg/day) and found that PNE offspring (P35/P36) had altered myelin expression of myelin-related transcription and trophic factors that produced alterations in myelin gene expression and oligodendrocyte functioning [165]

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In California, the average age to start smoking regularly is 17

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The decree further requires nico to submit a national study on urban cleaning waste in 2026, in line with EU guidelines, to help determine whether current cost estimates should be revised under existing European legislation that obliges tobacco producers to finance the clean-up and management of discarded filtered products