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Although chronic hives clear up in most cases, 15% of people continue to have symptoms at least twice weekly after 2 years

If the primary outcome showed superiority, secondary outcomes were tested in a pre-specified order to control the type I errors Total eGFR slope (the annual rate of change in eGFR from randomization to the end of the trial) Major cardiovascular events (a composite of nonfatal MI, nonfatal stroke, or death from CV causes) Death from any cause The other supportive secondary outcomes are shown in the figure below

Another option is to use an intrauterine device (IUD)