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All original studies investigating the difference between the levels of any new-generation antidepressive agents (SSRI, SNRI, trazodone, mirtazapine, bupropion or agomelatine) and the smoking status were eligible for this systematic review

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Because there are therapies with evidence of favourable benefit-to-harm profiles, using therapies with very uncertain evidence of effectiveness is an important opportunity cost in that a potentially effective intervention is not attempted