Though DAM has been detected across multiple neurological disease models, the composition of disease related microglia and macrophage clusters differs between diseasephagocytic subtype predominant in AD, while inflammatory subtype predominant in ALS (Wishart et al., 2023)
It also reduced the mucosal myeloperoxidase activity, lipid peroxidation (MDA), and the inflammatory cytokines (TNF- , IL-1 , and IL-6) as compared to untreated control group
In addition, there were significant differences in the percent changes in arm muscle area, hand grip strength, and lean body mass after 12 months between the two groups [142]
Histological and immunohistochemical analysis of the thyroid showed that after the exposure there was a relative increase in the appearance of follicles at rest with a consequent decrease in the number of active follicles, in addition to the appearance of macrophages, dilated follicles and flattened epithelium, with decreased volume of colloid
and (iso)citrate, m/z 459
