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Measurement of HCV RNA before treatment and again after 12 weeks of treatment is useful to monitor patients with genotype 114,38-41 and, according to the present knowledge, also those with genotype 4, 5 and 6.42 A 2-log drop at least or undetectable HCV RNA at week 12, is defined as early virological response (EVR)38 which is now believed to have a poor positive predictive value but an excellent negative predictive value to sustained virological response (SVR)

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