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Psychological adjustment does not automatically parallel somatic change: in obesity, perceived stress mediates the association between bodyimage disturbance and depressive symptoms [72], and after bariatric surgery, improvements in depression appear to be mediated by bodyimage change rather than weight loss per se [73]

doi: 10.1002/jbmr.1691

2020;370:m3342

There are no head-to-head comparisons with popular drugs that have already been approved for weight-loss, but general numbers give some clues

Diabetic Macular Oedema develops when prolonged high blood sugar damages retinal blood vessels, causing fluid accumulation in the macula and progressive vision loss