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The age-related difference stems from declining metabolic rate, reduced muscle mass, hormonal changes, and accumulated metabolic damage from years of obesity

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GLP-1 + VP infusion exhibited significant reduction in infarct size in both isolated and intact heart compared to the control group (VP group or saline group)

This disruption may lead to reduced secretion of luteinising hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland, ultimately resulting in anovulation (absence of ovulation) and menstrual irregularities, including missed periods