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Toxicology, 102(1-2), 189-196

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2020;318(3):G55473

FIGURE 9 Discussion Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease characterized by a complex pathogenesis involving multiple interrelated processes, including intestinal barrier disruption, oxidative stress imbalance, excessive inflammatory activation, gut microbiota dysbiosis, and metabolic disturbances ( Body weight loss, colon shortening, and histological damage are hallmark pathological features of the DSS-induced UC model and serve as key metrics for evaluating therapeutic interventions

Finally, the odds ratios (ORs) and 95% CIs were calculated to provide evidence for an underlying causal association of expression of the GLP1R gene with the risk of DR and different severity of DR