8 In our study, complete loss of expression of H3K27me3 was observed in 37% of melanomas, with 25% of primary desmoplastic/fusiform cells melanomas
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Some healthcare providers may choose to implement a stepwise dose reduction (for example, decreasing from 15 mg to 10 mg to 5 mg over several weeks) not because tapering is pharmacologically required, but to allow time for: Transitioning to alternative therapies Implementing lifestyle modifications Monitoring metabolic parameters Adjusting other medications Psychological preparation for treatment changes This approach represents clinical judgment rather than medical necessity
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