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The included studies encompassed a variety of study designs, including randomized controlled trials (RCTs), observational studies, and systematic reviews

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Mutation of Thr 15 and Thr 365 to alanine yielded mutant enzymes that are active and produce similar quantities of SGE with wild-type, suggesting that the interactions of Thr 15 and Thr 365 with SA are not essential for SGE formation

By disrupting the interaction between FOXO4 and p53, FOXO4-DRI reactivates apoptosis in aged cells, clearing them from tissues and promoting systemic rejuvenation (1, 2)

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